Time Derivative

MS: ✗
BD: ✗

This module will calculte g(s) differential sedimentation profiles by subtracting consectutive scan pairs from each other and mapping the resulting difference curves to the S domain to obtain dc/dt curves.

The advantage of this method is its ability to nicely subtract out time invariant noise. Unlike the van Holde-Weischet module, the Time Derivative method does not correct for diffusion. In order to obtain accurate results, it is important to use only a small scan range over which diffusion has not change significantly.

Analysis Controls

Data Smoothing Choose the number of points to use for any smoothing of raw input data.

Boundary Pos. (%) Choose the percent of the plateau-baseline range that is to be added to the baseline to form the beginning of analysis span.

S-value Cutoff Choose the sedimentation coefficient value to form the maximum X value of the Time Derivative plot.

Graph Selection

x:radius Select this radio button to choose a g*(S) versus radius dC/dt plot.

x:S Select this radio button to choose a g*(S) versus sedimentation coefficient dC/dt plot.

Average S Select this radio button to choose an Average g*(S) versus sedimentation coefficient dC/dt plot.